The Fifth Transmembrane Domain of Angiotensin II Type 1 Receptor Participates in the Formation of the Ligand-binding Pocket and Undergoes a Counterclockwise Rotation upon Receptor Activation

The octapeptide hormone angiotensin II exerts a wide variety of cardiovascular effects through the activation of the angiotensin II Type 1 (AT(1)) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein- coupled receptors, the AT(1) receptor possesses seven transm...

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Main Authors: Domazet, Ivana, Martin, Stéphane S., Holleran, Brian J., Morin, Marie-Ève, Lacasse, Patrick, Lavigne, Pierre, Escher, Emanuel, Leduc, Richard, Guillemette, Gaétan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797267/
https://ncbi.nlm.nih.gov/pubmed/19773549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051839
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