Substrate Binding and Active Site Residues in RNases E and G: ROLE OF THE 5′-SENSOR

The paralogous endoribonucleases, RNase E and RNase G, play major roles in intracellular RNA metabolism in Escherichia coli and related organisms. To assay the relative importance of the principal RNA binding sites identified by crystallographic analysis, we introduced mutations into the 5′-sensor,...

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Autori principali: Garrey, Stephen M., Blech, Michaela, Riffell, Jenna L., Hankins, Janet S., Stickney, Leigh M., Diver, Melinda, Hsu, Ying-Han Roger, Kunanithy, Vitharani, Mackie, George A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
RNA: Processing and Catalysis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797255/
https://ncbi.nlm.nih.gov/pubmed/19778900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.063263
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