Conserved Negative Charges in the N-terminal Tetramerization Domain Mediate Efficient Assembly of Kv2.1 and Kv2.1/Kv6.4 Channels

Voltage-gated potassium (Kv) channels are transmembrane tetramers of individual α-subunits. Eight different Shaker-related Kv subfamilies have been identified in which the tetramerization domain T1, located on the intracellular N terminus, facilitates and controls the assembly of both homo- and hete...

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Bibliographic Details
Main Authors: Bocksteins, Elke, Labro, Alain J., Mayeur, Evy, Bruyns, Tine, Timmermans, Jean-Pierre, Adriaensen, Dirk, Snyders, Dirk J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797233/
https://ncbi.nlm.nih.gov/pubmed/19717558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039479
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