Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

The human promyelocytic leukemia cell line HL-60 overexpresses the c-myc protooncogene. A calculated secondary structure for c-myc mRNA placed the initiation codon in a bulge of a weakly base-paired region. Treatment of HL-60 cells with 5' d(AACGTTGAGGGGCAT) 3', complementary to the initia...

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Detalles Bibliográficos
Main Authors: Wickstrom, E L, Bacon, T A, Gonzalez, A, Freeman, D L, Lyman, G H, Wickstrom, E
Formato: Artigo
Idioma:Inglês
Publicado: 1988
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC279694/
https://ncbi.nlm.nih.gov/pubmed/3277186
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