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Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

The human promyelocytic leukemia cell line HL-60 overexpresses the c-myc protooncogene. A calculated secondary structure for c-myc mRNA placed the initiation codon in a bulge of a weakly base-paired region. Treatment of HL-60 cells with 5' d(AACGTTGAGGGGCAT) 3', complementary to the initiation codon...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wickstrom, E L, Bacon, T A, Gonzalez, A, Freeman, D L, Lyman, G H, Wickstrom, E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279694/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3277186/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1028
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