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Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice
The lipid peroxidation product 4-hydroxynonenal (4-HNE) forms as a consequence of oxidative stress. By electrophilic attack on biological macromolecules, 4-HNE mediates signaling or may cause toxicity. A major route of 4-HNE disposal is via glutathione conjugation, in the mouse catalyzed primarily b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796882/ https://ncbi.nlm.nih.gov/pubmed/19880816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp165 |
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