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Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis
The HPV-oncoprotein, E7 promotes proteasomal degradation of the tumor suppressor protein, Rb. In this study, we analyzed the regulation of E7-induced Rb proteolysis in HPV-containing Caski cervical cancer cells. We show that the Rb proteolysis is cell cycle dependent; in S phase Rb is stable while i...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796474/ https://ncbi.nlm.nih.gov/pubmed/19906396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.10.018 |
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