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The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms

DNA damage checkpoint pathways operate to prevent cell cycle progression in response to DNA damage and replication stress. In S. cerevisiae, Mec1-Ddc2 (human ATR-ATRIP) is the principal checkpoint protein kinase. Biochemical studies have identified two factors, the 9-1-1 checkpoint clamp and the Dpb...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Navadgi-Patil, Vasundhara M., Burgers, Peter M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796261/
https://ncbi.nlm.nih.gov/pubmed/20005839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.014
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