Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

BACKGROUND: Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to...

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Autors principals: Yokota, N, Koizume, S, Miyagi, E, Hirahara, F, Nakamura, Y, Kikuchi, K, Ruf, W, Sakuma, Y, Tsuchiya, E, Miyagi, Y
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
Matèries:
Molecular Diagnostics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795428/
https://ncbi.nlm.nih.gov/pubmed/19904262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605406
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