Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

BACKGROUND: Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to...

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Detalhes bibliográficos
Main Authors: Yokota, N, Koizume, S, Miyagi, E, Hirahara, F, Nakamura, Y, Kikuchi, K, Ruf, W, Sakuma, Y, Tsuchiya, E, Miyagi, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795428/
https://ncbi.nlm.nih.gov/pubmed/19904262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605406
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