Hierarchical rules for Argonaute loading in Drosophila

Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the...

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Bibliografske podrobnosti
Main Authors: Czech, Benjamin, Zhou, Rui, Erlich, Yaniv, Brennecke, Julius, Binari, Richard, Villalta, Christians, Gordon, Assaf, Perrimon, Norbert, Hannon, Gregory J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795325/
https://ncbi.nlm.nih.gov/pubmed/19917252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.028
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