Accelerated autoxidation and heme loss due to instability of sickle hemoglobin.

The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be involved in sickle disease pathobiology. We have examined rates of heme transfer to hemopexin from hemoglobin in dilute aqueous solution (0.5 mg of Hb per ml) at 37 degre...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Hebbel, R P, Morgan, W T, Eaton, J W, Hedlund, B E
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1988
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279519/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422420/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.1.237
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