Accelerated autoxidation and heme loss due to instability of sickle hemoglobin.
The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be involved in sickle disease pathobiology. We have examined rates of heme transfer to hemopexin from hemoglobin in dilute aqueous solution (0.5 mg of Hb per ml) at 37 degre...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1988
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279519/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3422420/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.1.237 |
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