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Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans

BACKGROUND: Beat to beat alternans of cellular repolarization is closely linked to ventricular arrhythmias in humans. We hypothesized that sarcoplasmic reticulum calcium reuptake by SERCA2a plays a central role in the mechanism of cellular alternans and increasing SERCA2a gene expression will retard...

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Detalhes bibliográficos
Main Authors: Cutler, Michael J., Wan, Xiaoping, Laurita, Kenneth R., Hajjar, Roger J., Rosenbaum, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795134/
https://ncbi.nlm.nih.gov/pubmed/19948504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.109.863118
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