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Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans
BACKGROUND: Beat to beat alternans of cellular repolarization is closely linked to ventricular arrhythmias in humans. We hypothesized that sarcoplasmic reticulum calcium reuptake by SERCA2a plays a central role in the mechanism of cellular alternans and increasing SERCA2a gene expression will retard...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795134/ https://ncbi.nlm.nih.gov/pubmed/19948504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.109.863118 |
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