Impaired skin and mammary gland development and increased γ-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1

The tumor suppressor BRCA1 interacts with many proteins, and undergoes multiple modifications upon DNA damage. ATM, a key molecule of the DNA damage response, phosphorylates S1189 of BRCA1 after γ-irradiation. S1189 of BRCA1 is known as a unique ATM phosphorylation site in BRCA1 exon 11. To study th...

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Bibliographic Details
Main Authors: Kim, Sang Soo, Cao, Liu, Baek, Hye Jung, Lim, Sung-Chul, Li, Cuiling, Wang, Rui-Hong, Xu, Xiaoling, Cho, Kwan Ho, Deng, Chu-Xia
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795111/
https://ncbi.nlm.nih.gov/pubmed/19996295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2418
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