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Contralateral Paw Sensitization Following Injection of Endothelin-1: Effects of local anesthetics differentiate peripheral and central processes

Subcutaneous injection of the peptide endothelin-1 (ET-1) into the rat’s footpad is known to cause rapid, transient ipsilateral mechanical and thermal sensitization and nocifensive hind paw flinching. Here we report that local injection of ET-1 (2 nmoles) into one hind paw slowly sensitizes the cont...

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Autores principales: Khodorova, Alla, Strichartz, Gary R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795047/
https://ncbi.nlm.nih.gov/pubmed/19874873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.10.049
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