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The p75(NTR) SIGNALING CASCADE MEDIATES MECHANICAL HYPERALGESIA INDUCED BY NERVE GROWTH FACTOR INJECTED INTO THE RAT HIND PAW

Nerve Growth Factor (NGF) augments excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75(NTR)) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceramide, and the atypical PKC (aPKC), PKMζ, are key mediat...

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Bibliografiske detaljer
Main Authors: Khodorova, Alla, Nicol, Grant D., Strichartz, Gary
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848252/
https://ncbi.nlm.nih.gov/pubmed/24095693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.09.046
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