Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging

Previous studies have shown that inhibition of the Ca(2+)-/calmodulin-dependent protein phosphatase calcineurin (CN) blocks L-type voltage sensitive Ca(2+) channel (L-VSCC) activity in cultured hippocampal neurons. However, it is not known whether CN contributes to the increase in hippocampal L-VSCC...

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Detalhes bibliográficos
Main Authors: Norris, Christopher M., Blalock, Eric M., Chen, Kuey-Chu, Porter, Nada M., Thibault, Olivier, Kraner, Susan D., Landfield, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795015/
https://ncbi.nlm.nih.gov/pubmed/18471936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2008.03.026
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