Single doublecortin gene therapy significantly reduces glioma tumor volume

We employed lentivirus based doublecortin (DCX), as a glioma suppressor gene therapy in an intracranial glioma tumor xenograft model in nude rats. Single DCX expressing lentivirus was directly administered into the tumor on day 8 after U87 tumor cell implantation. DCX treatment significantly reduced...

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Bibliographic Details
Main Authors: Santra, Manoranjan, Zheng, Xuguang, Roberts, Cindi, Santra, Sutapa, Lu, Mei, Panda, Swayamprava, Jiang, Feng, Chopp, Michael
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795007/
https://ncbi.nlm.nih.gov/pubmed/19681167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22207
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