MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β Cells

Pdx-1 (pancreatic-duodenal homeobox-1), a MODY4 homeodomain transcription factor, serves as a master regulator in the pancreas because of its importance during organogenesis and in adult islet insulin-producing β cell activity. Here, we show that KLF11, an SP/Krüppel-like (SP/KLF) transcription fact...

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Hlavní autoři: Fernandez-Zapico, Martin E., van Velkinburgh, Jennifer C., Gutiérrez-Aguilar, Ruth, Neve, Bernadette, Froguel, Philippe, Urrutia, Raul, Stein, Roland
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Transcription, Chromatin, and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794764/
https://ncbi.nlm.nih.gov/pubmed/19843526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028852
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