Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3β-Hydroxysterol Δ24-Reductase

Persistent infection with hepatitis C virus (HCV) induces tumorigenicity in hepatocytes. To gain insight into the mechanisms underlying this process, we generated monoclonal antibodies on a genome-wide scale against an HCV-expressing human hepatoblastoma-derived cell line, RzM6-LC, showing augmented...

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Detalhes bibliográficos
Main Authors: Nishimura, Tomohiro, Kohara, Michinori, Izumi, Kosuke, Kasama, Yuri, Hirata, Yuichi, Huang, Ying, Shuda, Masahiro, Mukaidani, Chise, Takano, Takashi, Tokunaga, Yuko, Nuriya, Hideko, Satoh, Masaaki, Saito, Makoto, Kai, Chieko, Tsukiyama-Kohara, Kyoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794760/
https://ncbi.nlm.nih.gov/pubmed/19861417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043232
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