Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3β-Hydroxysterol Δ24-Reductase

Persistent infection with hepatitis C virus (HCV) induces tumorigenicity in hepatocytes. To gain insight into the mechanisms underlying this process, we generated monoclonal antibodies on a genome-wide scale against an HCV-expressing human hepatoblastoma-derived cell line, RzM6-LC, showing augmented...

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Hlavní autoři: Nishimura, Tomohiro, Kohara, Michinori, Izumi, Kosuke, Kasama, Yuri, Hirata, Yuichi, Huang, Ying, Shuda, Masahiro, Mukaidani, Chise, Takano, Takashi, Tokunaga, Yuko, Nuriya, Hideko, Satoh, Masaaki, Saito, Makoto, Kai, Chieko, Tsukiyama-Kohara, Kyoko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794760/
https://ncbi.nlm.nih.gov/pubmed/19861417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043232
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