On the Mechanism Underlying (23S)-25-Dehydro-1α(OH)-vitamin D(3)-26,23-lactone Antagonism of hVDRwt Gene Activation and Its Switch to a Superagonist

(23S)-25-Dehydro-1α(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1α,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. To study the mode of antagonism of MK an hVDR mutant libra...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mizwicki, Mathew T., Bula, Craig M., Mahinthichaichan, Paween, Henry, Helen L., Ishizuka, Seiichi, Norman, Anthony W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794745/
https://ncbi.nlm.nih.gov/pubmed/19801650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042069
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