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On the Mechanism Underlying (23S)-25-Dehydro-1α(OH)-vitamin D(3)-26,23-lactone Antagonism of hVDRwt Gene Activation and Its Switch to a Superagonist
(23S)-25-Dehydro-1α(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1α,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. To study the mode of antagonism of MK an hVDR mutant libra...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794745/ https://ncbi.nlm.nih.gov/pubmed/19801650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042069 |
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