An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

BACKGROUND: MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this study was to evaluate anti-lymphoma activity of MI-319 in WSU-FSCCL, a B-cell f...

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Autori principali: Mohammad, Ramzi M, Wu, Jack, Azmi, Asfar S, Aboukameel, Amro, Sosin, Angela, Wu, Sherwin, Yang, Dajun, Wang, Shaomeng, Al-Katib, Ayad M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794250/
https://ncbi.nlm.nih.gov/pubmed/19958544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-115
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