Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis

Macrophages mediate kidney disease and are prominent in a mouse model (MRL-Fas(lpr)) of lupus nephritis. Colony stimulating factor-1 (CSF-1) is the primary growth factor for macrophages, and CSF-1 deficiency protects MRL-Fas(lpr) mice from kidney disease and systemic illness. Whether this renoprotec...

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Main Authors: Menke, Julia, Rabacal, Whitney A., Byrne, Katelyn T., Iwata, Yasunori, Schwartz, Melvin M., Stanley, E. Richard, Schwarting, Andreas, Kelley, Vicki R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2009
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794229/
https://ncbi.nlm.nih.gov/pubmed/19926892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009050499
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