Rehosting of Bacterial Chaperones for High-Quality Protein Production

Coproduction of DnaK/DnaJ in Escherichia coli enhances solubility but promotes proteolytic degradation of their substrates, minimizing the yield of unstable polypeptides. Higher eukaryotes have orthologs of DnaK/DnaJ but lack the linked bacterial proteolytic system. By coexpression of DnaK and DnaJ...

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Bibliografiske detaljer
Main Authors: Martínez-Alonso, Mónica, Toledo-Rubio, Verónica, Noad, Rob, Unzueta, Ugutz, Ferrer-Miralles, Neus, Roy, Polly, Villaverde, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794089/
https://ncbi.nlm.nih.gov/pubmed/19820142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01532-09
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