Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation, potential implications for COX-2 inhibition

Recent increased adverse cardiovascular events observed with selective cyclooxygenase-2 (COX-2) inhibition led to the withdrawal of rofecoxib (Vioxx) and valdecoxib (Bextra), but the mechanisms underlying these atherothrombotic events remain unclear. Prostacyclin is the major endproduct of COX-2 in...

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Autors principals: Arehart, Eric, Stitham, Jeremiah, Asselbergs, Folkert W., Douville, Karen, MacKenzie, Todd, Fetalvero, Kristina M., Gleim, Scott, Kasza, Zsolt, Rao, Yamini, Martel, Laurie, Segel, Sharon, Robb, John, Kaplan, Aaron, Simons, Michael, Powell, Richard J., Moore, Jason H., Rimm, Eric B., Martin, Kathleen A., Hwa, John
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793685/
https://ncbi.nlm.nih.gov/pubmed/18323528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.107.165936
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