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Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Therapeutic glycoproteins have played a major role in the commercial success of biotechnology in the post-genomic era. But isolating recombinant mammalian cell lines for large-scale production remains costly and time-consuming, due to substantial variation and unpredictable stability of expression a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pilbrough, Warren, Munro, Trent P., Gray, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793030/
https://ncbi.nlm.nih.gov/pubmed/20037651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008432
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