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Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells
Therapeutic glycoproteins have played a major role in the commercial success of biotechnology in the post-genomic era. But isolating recombinant mammalian cell lines for large-scale production remains costly and time-consuming, due to substantial variation and unpredictable stability of expression a...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793030/ https://ncbi.nlm.nih.gov/pubmed/20037651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008432 |
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