JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the stress protection pathway. SIRT1 deacetylates a number of protein substrates, including histones, FOXOs, PGC-1α, and p53, leading to cellular protection. We identified a functional interaction between cJUN N-term...

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Detalhes bibliográficos
Main Authors: Nasrin, Nargis, Kaushik, Virendar K., Fortier, Eric, Wall, Daniel, Pearson, Kevin J., de Cabo, Rafael, Bordone, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793009/
https://ncbi.nlm.nih.gov/pubmed/20027304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008414
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