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Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

Farnesyltransferase inhibitors (FTIs) exhibit the remarkable ability to inhibit transformed phenotypes of a variety of human cancer cell lines and to block the growth of cancer cells in a number of animal model systems. In this paper, we report that the addition of FTI to v-K-ras- transformed NRK ce...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Suzuki, Nobutaka, Del Villar, Keith, Tamanoi, Fuyuhiko
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27923/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9724732/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.18.10499
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