High Titer HIV-1 V3-Specific Antibodies with Broad Reactivity but Low Neutralizing Potency in Acute Infection and Following Vaccination

Identifying the earliest neutralizing antibody specificities that are elicited following infection or vaccination by HIV-1 is an important objective of current HIV/AIDS vaccine research. We have shown previously that transplantation of HIV-1 V3 epitopes into an HIV-2 envelope (Env) scaffold provides...

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Detalhes bibliográficos
Main Authors: Davis, Katie L., Gray, Elin S., Moore, Penny L., Decker, Julie M., Salomon, Aidy, Montefiori, David C., Graham, Barney S., Keefer, Michael C., Pinter, Abraham, Morris, Lynn, Hahn, Beatrice H., Shaw, George M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792036/
https://ncbi.nlm.nih.gov/pubmed/19298995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.02.022
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