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Development of Broadly Neutralizing Antibodies from Autologous Neutralizing Antibody Responses
PURPOSE OF REVIEW: Detailed genetic and structural characterization has revealed that broadly neutralizing antibodies (bnAbs) against HIV-1 have unusually high levels of somatic hypermutation, long CDRH3 domains, and the ability to target one of four sites of vulnerability on the HIV-1 envelope (Env...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068799/ https://ncbi.nlm.nih.gov/pubmed/24662931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0000000000000057 |
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