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Use of high throughput sequencing to observe genome dynamics at a single cell level

With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced several genomes of Escherichia coli from colo...

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Detalhes bibliográficos
Main Authors: Parkhomchuk, D., Amstislavskiy, V., Soldatov, A., Ogryzko, V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791585/
https://ncbi.nlm.nih.gov/pubmed/19934054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906681106
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