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Molecular interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration

A macromolecular nucleoprotein complex in retrovirus-infected cells, termed the preintegration complex, is responsible for the concerted integration of linear viral DNA genome into host chromosomes. Isolation of sufficient quantities of the cytoplasmic preintegration complexes for biochemical and bi...

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Autors principals: Bera, Sibes, Pandey, Krishan K., Vora, Ajaykumar C., Grandgenett, Duane P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791363/
https://ncbi.nlm.nih.gov/pubmed/19362096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.007
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