The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is reported to cause apoptosis of infected cells and several of its proteins including the 3a accessory protein, are pro-apoptotic. Since the 3a protein localizes to the endoplasmic reticulum (ER)-Golgi compartment, its role in causing ER...

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Detalhes bibliográficos
Main Authors: Minakshi, Rinki, Padhan, Kartika, Rani, Manjusha, Khan, Nabab, Ahmad, Faizan, Jameel, Shahid
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791231/
https://ncbi.nlm.nih.gov/pubmed/20020050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008342
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