An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

BACKGROUND: The down-regulation of the major histocompatibility complex class I (MHC-I) from the surface of infected cells by the Nef proteins of primate immunodeficiency viruses likely contributes to pathogenesis by providing evasion of cell-mediated immunity. HIV-1 Nef-induced down-regulation invo...

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Autores principales: Singh, Rajendra Kumar, Lau, David, Noviello, Colleen M., Ghosh, Partho, Guatelli, John C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791223/
https://ncbi.nlm.nih.gov/pubmed/20020046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008364
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