TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Tumor necrosis factor (TNF) receptor-associated factor-2 (TRAF2) binds to cIAP1 and cIAP2 (cIAP1/2) and recruits them to the cytoplasmic domain of several members of the TNF receptor (TNFR) superfamily, including the TNF-TNFR1 ligand-receptor complex. Here, we define a cIAP1/2-interacting motif (CIM...

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Detalhes bibliográficos
Main Authors: Vince, James E., Pantaki, Delara, Feltham, Rebecca, Mace, Peter D., Cordier, Stephanie M., Schmukle, Anna C., Davidson, Angelina J., Callus, Bernard A., Wong, Wendy Wei-Lynn, Gentle, Ian E., Carter, Holly, Lee, Erinna F., Walczak, Henning, Day, Catherine L., Vaux, David L., Silke, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791019/
https://ncbi.nlm.nih.gov/pubmed/19815541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072256
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