TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth, therefore its role in adult tissues is not well-explored. Furthermore, the role of the TRAF2 RING is controversial. It ha...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Etemadi, Nima, Chopin, Michael, Anderton, Holly, Tanzer, Maria C, Rickard, James A, Abeysekera, Waruni, Hall, Cathrine, Spall, Sukhdeep K, Wang, Bing, Xiong, Yuquan, Hla, Timothy, Pitson, Stuart M, Bonder, Claudine S, Wong, Wendy Wei-Lynn, Ernst, Matthias, Smyth, Gordon K, Vaux, David L, Nutt, Stephen L, Nachbur, Ueli, Silke, John
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2015
Aiheet:
Biochemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769158/
https://ncbi.nlm.nih.gov/pubmed/26701909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10592
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