Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon cancer. Because GSK3 is a key component of both pathways, it is widely assumed that active PI3K signaling feeds positi...

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Detalhes bibliográficos
Main Authors: Ng, Ser Sue, Mahmoudi, Tokameh, Danenberg, Esther, Bejaoui, Inés, de Lau, Wim, Korswagen, Hendrik C., Schutte, Mieke, Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790960/
https://ncbi.nlm.nih.gov/pubmed/19850932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078261
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