Oxidative Stress Decreases Phosphatidylinositol 4,5-Bisphosphate Levels by Deactivating Phosphatidylinositol- 4-phosphate 5-Kinase β in a Syk-dependent Manner

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) has many essential functions and its homeostasis is highly regulated. We previously found that hypertonic stress increases PIP(2) by selectively activating the β isoform of the type I phosphatidylinositol phosphate 5-kinase (PIP5Kβ) through Ser/Thr deph...

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Detalhes bibliográficos
Main Authors: Chen, Mark Z., Zhu, Xiaohui, Sun, Hui-Qiao, Mao, Yuntao S., Wei, Yongjie, Yamamoto, Masaya, Yin, Helen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749148/
https://ncbi.nlm.nih.gov/pubmed/19553680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036509
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