Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer

INTRODUCTION: MUC1 is a cell-surface glycoprotein that establishes a molecular barrier at the epithelial surface and engages in morphogenetic signal transduction. Alterations in MUC1 glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adh...

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Detalhes bibliográficos
Main Authors: Pegram, Mark D, Borges, Virginia F, Ibrahim, Nuhad, Fuloria, Jyotsna, Shapiro, Charles, Perez, Susan, Wang, Karen, Schaedli Stark, Franziska, Courtenay Luck, Nigel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790853/
https://ncbi.nlm.nih.gov/pubmed/19811637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2409
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