Determination of methotrexate and its major metabolite 7‐hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography‐tandem mass spectrometry

Methotrexate [MTX] is an anticancer agent that is widely used in a variety of human cancers including primary central nervous system lymphoma [PCNSL]. Important pharmacological properties that directly bear on the use of MTX in PCNSL, such as mechanisms that govern its uptake into brain tumors, are...

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Hlavní autoři: Guo, Ping, Wang, Xiaomin, Liu, Liansheng, Belinsky, Martin G., Kruh, Gary D., Gallo, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790826/
https://ncbi.nlm.nih.gov/pubmed/17289326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2006.12.034
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