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Determination of methotrexate and its major metabolite 7‐hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography‐tandem mass spectrometry
Methotrexate [MTX] is an anticancer agent that is widely used in a variety of human cancers including primary central nervous system lymphoma [PCNSL]. Important pharmacological properties that directly bear on the use of MTX in PCNSL, such as mechanisms that govern its uptake into brain tumors, are...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790826/ https://ncbi.nlm.nih.gov/pubmed/17289326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2006.12.034 |
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