Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition

We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1 inhibitors from olive leaf extracts effective against viral fusion and integration. We used molecular docking simulation to study the interactions of Ole and HT with viral targets. We find that Ole and HT bind to...

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Hlavní autoři: Lee-Huang, Sylvia, Huang, Philip Lin, Zhang, Dawei, Lee, Jae Wook, Bao, Ju, Sun, Yongtao, Chang, Young-Tae, Zhang, John, Huang, Paul Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790717/
https://ncbi.nlm.nih.gov/pubmed/17275783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.071
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