Discovery of Small-Molecule HIV-1 Fusion and Integrase Inhibitors Oleuropein and Hydroxytyrosol: II. Integrase Inhibition

We report molecular modeling and functional confirmation of Ole and HT binding to HIV-1 integrase. Docking simulations identified two binding regions for Ole within the integrase active site. Region I encompasses the conserved D64-D116-E152 motif, while region II involves the flexible loop region fo...

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Main Authors: Lee-Huang, Sylvia, Huang, Philip Lin, Zhang, Dawei, Lee, Jae Wook, Bao, Ju, Sun, Yongtao, Chang, Young-Tae, Zhang, John, Huang, Paul Lee
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857318/
https://ncbi.nlm.nih.gov/pubmed/17261269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.058
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