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Recruitment of Rad51 and Rad52 to Short Telomeres Triggers a Mec1-Mediated Hypersensitivity to Double-Stranded DNA Breaks in Senescent Budding Yeast

Telomere maintenance is required for chromosome stability, and telomeres are typically replicated by the action of telomerase. In both mammalian tumor and yeast cells that lack telomerase, telomeres are maintained by an alternative recombination mechanism. Here we demonstrated that the budding yeast...

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Autori principali: Lin, Yi-Hsuan, Chang, Chia-Ching, Wong, Chui-Wei, Teng, Shu-Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790616/
https://ncbi.nlm.nih.gov/pubmed/20011546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008224
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