Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair

RAD52 is a homologous recombination (HR) protein that is conserved from bacteriophage to humans. Simultaneously attenuating expression of both the RAD52 gene, and the HR and tumor suppressor gene, BRCA2, in human cells synergistically reduces HR – indicating that RAD52 and BRCA2 control independent...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Manthey, Glenn M., Clear, Alissa D., Liddell, Lauren C., Negritto, Maria C., Bailis, Adam M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389729/
https://ncbi.nlm.nih.gov/pubmed/27923995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1228
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