Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity

Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not completely known. To examine its effect on tumorigen...

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Hauptverfasser: Hamm, Christopher A., Xie, Hehuang, Costa, Fabricio F., Vanin, Elio F., Seftor, Elisabeth A., Sredni, Simone T., Bischof, Jared, Wang, Deli, Bonaldo, Maria F., Hendrix, Mary J. C., Soares, Marcelo B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790612/
https://ncbi.nlm.nih.gov/pubmed/20019818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008340
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